| Description: | Synthetic cannabinoids researchers manufactured synthetic cannabinoids focusing on THC. Synthetic marijuana replaced natural cannabinoids which went illegal. Thus, many are useful because they bind selectively to either the CB1 or CB2 receptors. However, THC has a similar affinity for both. Clinicians used some early synthetic cannabinoids in hospitals. They used Nabilone, a first generation synthetic THC analog, as an antiemetic to combat vomiting and nausea since 1981. Also, clinicians used synthetic THC (marinol, dronabinol) as an antiemetic since 1985, and an appetite stimulant since 1991. In the early 2000s, US and European citizens began using k2 incense for recreational drug use in an attempt to get similar effects to cannabis. Because synthetic cannabinoid molecular structures differ from THC and other illegal cannabinoids. Thus, state officials did not render spice illegal. In 2008, state officials discovered the recreational use of k2. Thus, some synthetic k2 spice were made illegal. However, manufacturers synthesise new analogs to avoid the restrictions. Recreational consumers use synthetic spice because they are inexpensive. |